KEGG   Homo sapiens (human): 2872
Entry
2872              CDS       T01001                                 
Symbol
MKNK2, GPRK7, MNK2
Name
(RefSeq) MAPK interacting serine/threonine kinase 2
  KO
K04372  MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04910  Insulin signaling pathway
Drug target
Merestinib: D11763
Tomivosertib (DG03019): D11452 D11481
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2872 (MKNK2)
   04066 HIF-1 signaling pathway
    2872 (MKNK2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    2872 (MKNK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2872 (MKNK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     2872 (MKNK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   2872 (MKNK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo zf-RRN7 ABC_trans_aux Pkinase_fungal
Other DBs
NCBI-GeneID: 2872
NCBI-ProteinID: NP_951009
OMIM: 605069
HGNC: 7111
Ensembl: ENSG00000099875
UniProt: Q9HBH9 B3KS07
Structure
Position
19:complement(2037471..2051244)
AA seq 465 aa
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
NT seq 1398 nt   +upstreamnt  +downstreamnt
atggtgcagaagaaaccagccgaacttcagggtttccaccgttcgttcaaggggcagaac
cccttcgagctggccttctccctagaccagcccgaccacggagactctgactttggcctg
cagtgctcagcccgccctgacatgcccgccagccagcccattgacatcccggacgccaag
aagaggggcaagaagaagaagcgcggccgggccaccgacagcttctcgggcaggtttgaa
gacgtctaccagctgcaggaagatgtgctgggggagggcgctcatgcccgagtgcagacc
tgcatcaacctgatcaccagccaggagtacgccgtcaagatcattgagaagcagccaggc
cacattcggagcagggttttcagggaggtggagatgctgtaccagtgccagggacacagg
aacgtcctagagctgattgagttcttcgaggaggaggaccgcttctacctggtgtttgag
aagatgcggggaggctccatcctgagccacatccacaagcgccggcacttcaacgagctg
gaggccagcgtggtggtgcaggacgtggccagcgccttggactttctgcataacaaaggc
atcgcccacagggacctaaagccggaaaacatcctctgtgagcaccccaaccaggtctcc
cccgtgaagatctgtgacttcgacctgggcagcggcatcaaactcaacggggactgctcc
cctatctccaccccggagctgctcactccgtgcggctcggcggagtacatggccccggag
gtagtggaggccttcagcgaggaggctagcatctacgacaagcgctgcgacctgtggagc
ctgggcgtcatcttgtatatcctactcagcggctacccgcccttcgtgggccgctgtggc
agcgactgcggctgggaccgcggcgaggcctgccctgcctgccagaacatgctgtttgag
agcatccaggagggcaagtacgagttccccgacaaggactgggcccacatctcctgcgct
gccaaagacctcatctccaagctgctggtccgtgacgccaagcagaggctgagtgccgcc
caagtcctgcagcacccctgggttcaggggtgcgccccggagaacaccttgcccactccc
atggtcctgcagaggaacagctgtgccaaagacctcacgtccttcgcggctgaggccatt
gccatgaaccggcagctggcccagcacgacgaggacctggctgaggaggaggccgcgggg
cagggccagcccgtcctggtccgagctacctcacgctgcctgcagctgtctccaccctcc
cagtccaagctggcgcagcggcggcaaagggccagtctgtcctcggccccagtggtcctg
gtgggagaccacgcctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (42)   
   RefSeq(nuc) (2)   
   GenBank (20)   
   EMBL (20)   
3D Structure (12)   
   PDB (12)   
Protein domain (6)   
   Pfam (6)   
All databases (100)   

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